试析传统经济的微博应用

通过介绍传统经济微博的发展,分析传统经济微博的类型和内容表述形式,对传统经济微博的特征进行总结分析,进一步提出传统经济微博发展中存在的问题,并给出相应的对策.     

Exogenous or endogenous Toll-like receptor ligands: which is the MVP in tumorigenesis?

Toll-like receptors (TLRs) are a class of pattern recognition receptors sensing microbial components and triggering an immune response against pathogens. In addition to their role in anti-infection immunity, increasing evidence indicates that engagement of TLRs can promote cancer cell survival and proliferation, induce tumor immune evasion, and enhance tumor metastasis and chemoresistance. Recent studies have demonstrated that endogenous molecules or damage-associated molecular patterns released from damaged/necrotic tissues are capable of activating TLRs and that the endogenous ligands-mediated TLR signaling is implicated in the tumor development and affects the therapeutic efficacy of tumors. Since both exogenous and endogenous TLR ligands can initiate TLR signaling, which is the most valuable player in tumor development becomes an interesting question. Here, we summarize the effect of TLR signaling on the development and progression of tumors, and discuss the role of exogenous and endogenous TLR ligands in the tumorigenesis.     

A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

太原市明秀寺的修缮设计方案与施工技术

明秀寺是太原地区保存较好、整体空间布局相对完整的一处传统形式的寺庙建筑群,具有较高的历史、科学和艺术价值。明秀寺除大殿曾维修过之外,其余建筑由于年久失修,多处部位出现险情。经系统勘测、综合分析、科学研究,提出了明秀寺的修缮设计方案与施工技术。     

基于遗传算法的PID控制器设计及仿真

分析了浮力调节装置实验系统的功能和结构,建立了数学模型.为了使控制器参数能够适应系统模型的改变,设计了基于遗传算法的自整定PID控制器,针对其液压系统中的多余压力提出了基于结构不变性原理的控制策略.对实验系统的控制模型进行仿真分析,结果表明：所设计的控制系统能够克服多余压力和模型参数时变2大控制难点,在不同的工况下能够始终保持良好的控制性能.     

中国籼稻亚种内的群体结构及地理生态分化

籼稻是亚洲和世界其他一些地区广为种植的主要栽培稻亚种,同时也是我国杂交水稻恢复系的主要来源.研究籼稻亚种内的遗传结构和遗传多样性对中国栽培稻亚种内的分类和演化以及水稻杂种优势利用具有重要的理论和实践意义.本研究通过36个SSR标记对1582份籼稻地方品种的群体结构和地理生态分化进行了分析.结果表明,利用分子标记所做基于模型和基于遗传距离的群体结构表现一致,即早籼稻生态型可划分为4个地理生态群,中间型生态型可划分为3个地理生态群,晚籼稻生态型可划分为2个地理生态群.当地的生态环境和空间隔离是形成地理分化的主要原因.地理生态群既体现了品种间的遗传差异又是对不同生态环境适应的反映,可用于籼稻亚种内杂种优势群划分的依据.根据SSR标记在各个生态型及地理生态群的基因型分布,筛选了可用于鉴别各生态型和地理生态群的SSR特征等位变异并建立了相应的SSR分子判别式.通过SSR分子判别式选择籼稻的中间类型开展籼粳杂种优势研究以及选择不同地理生态类型开展籼稻亚种内杂种优势研究,有助于突破籼粳杂种优势利用的障碍和加强籼稻亚种内杂种优势利用.     

Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.     

Single-Chain Fragmented Antibodies Guided SiRNA Delivery in Breast Cancer

Over the past ten years,the enthusiasm to harness small RNA molecules,mainly small interfering RNAs(siRNAs) and microRNA mimics,into therapeutic weapons has never been quenched.However,a major obstacle hindering the clinical application of these small molecules is how to efficiently and precisely deliver siRNAs in vivo into target cells to silence target genes.An international collaborative study led by Song Erwei from the Memorial Hospital of Sun-YatSen University and Wang Jun from Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences of University of Science and Tech-     

文化体制改革下的高校期刊发展研究

在文化体制改革的大背景下,高校期刊群必须要走出"大而全"、"小而大"的办刊思路,坚持走专业化、特色化的办刊道路,并牢牢把握特色与质量是高校期刊发展生命线这一主题,不断创新,实现特色兴刊、质量立刊、创新强刊的建设目标,实实在在地推进高校期刊群的发展,力争再为社会的发展繁荣做出新贡献。